Monday, January 27, 2020

How To Write An Economics Essay

How To Write An Economics Essay INTRODUCTION Writing on any essay topic can be a daunting task. Like most English compositions, an essay has a beginning, middle and an end. It is the way in which most students are taught to think about essay writing, starting with the thesis statement and then building an argument for or against the statement. Let’s face facts, not all students are born writers and struggle with the idea of writing an essay and possibly even fear the idea. Where does one begin, especially with the task of writing an Economics essay? Any writer specialising in academic writing would suggest starting with an understanding of a sub-subject found within the Economic realm. It may be that the course suggests what to write about and this will help with clarification purposes. Essay writing and writing in general can be a scary, personal task and one must find a comfort level with the subject first. Some subjects are easier, ‘softer’ to write about and the subject of Economics is not really one of them. The thesis or premise of the essay must be right on target and backed up by concise resources. Once one decides upon a sub-topic, it is best to figure out the thesis. Only then can one proceed to the next step of presenting the supporting evidence. This would be step two. Once the evidence is presented, then in order to score extra marks, it is always a good idea to present the thoughts and views of the opposition. From there, the essay can gain strength and the writer can start to present an original concept to the reader. It is in the latter part of the essay where one can take charge of exploring one’s ideas on the topic and establish his or her voice. This allows a nature progression toward the conclusion as the essay summates its main ideas and possibly leaves the reader with new questions and thoughts on the matter. FORMULATING THE THESIS The essay should have a strong, precise thesis statement. The thesis statement defines the essay, what it will be about and how the body of the essay will form to prove the thesis as true or false. The main objective is to remain focused on topic and have a thesis statement that can be researched as a relevant, current topic. It is always important to stick to the thesis and stay on topic. As a writer, sometimes tangents develop and it is important to stay away from the lard of essay writing. Always keep in mind, does this sentence, this paragraph answer the thesis? Is it relevant to the topic and discussion? By sticking to a relevant, current topic or event, for instance the American Bailout of Corrupt Financial Institutions, this not only allows one’s own opinions to form but also a solid argument to evolve. Essays should have passion once the thesis has been established and can be supported. WHERE TO LOOK FOR INFORMATION Half of the battle is won once the thesis takes shape and one has a better idea of what to discuss. It is time to start searching for information to support the thesis. In this day and age of telecommunications technology, email and the Internet, the most popular and accepted place to start research, one would think, would be online. Use discretion here and follow the professor’s guidelines. Sometimes Internet sources, even the most up to date are misleading and counterfeit. For the subject of Economics, especially with a global, multi-national point of view, it is best to start with a reputable magazine called The Economist. Here one will find the highest quality of information on the current event of the American Bailout. There is an online version, but also a trip to the library is encouraged. From there in order to get a feeling of the impact of such a current event, look to highly reputable international newspapers like the London Telegraph and the New York Times. Since t he Bailout has been a political issue, one can also read the Washington Post. One must always question the validity of the source. Part of being a good writer is constantly questioning the information and looking for answers where one would least expect them. PRESENTING DIFFERENT SIDES The quality of research also allows the writer to present different views as a means of exploring the thesis and even testing the validity of the thesis. The essay could even result in presenting facts that allows the thesis to be discredited. This also allows the writer flexibility and suggests they are not afraid of critical review. Research and writing about the opposition carries weight because it allows the essay a sense of balance. Here the local view on the topic is important to review and surmise. This is where the original idea and discussion can formulate. The local level view of the issue allows for passion but also gives a community voice. It is a good idea to read editorials but also get the view of the average person. From here, a flood of thought processes can result and by outlining the exploration allows the writer to pinpoint important elements of each view. This creates an elegant framework for the thesis to live but also presents thoughtful relevant ideas. THE ORIGINAL IDEA The idea that every essay should have an original idea is the scariest part of formulating the thesis and body of the paper. Will this happen at all? Sometimes it can be difficult to be in the mindset that it can. Have others thought the same? Possibly but do not hold back. Pressure really haunts the process of original writing. It is important to outwit one’s self into thinking. A lot times, people want to only focus on the thesis and accurately supporting the thesis. A good professor of any subject but especially business subjects should encourage steps toward original ideas and creativity. CONCLUSION A conclusion will act to summarise the purpose of the essay and restate the thesis statement as if to remind the reader about the subject and relevance of the topic. It is important to maybe leave the reader with thought provoking ideas as well as a sense of being finished. For this purpose, this essay acted as a means to instruct one how to write an economics essay but also offered insight on how to become a better writer.

Sunday, January 19, 2020

Succubus Revealed Chapter 2

It took me a moment to really comprehend that in thirty seconds, the conversation had gone from a deeply seriously mystery about my love life to bowling for demonic bragging rights. And yet, this wasn't a particularly unusual pattern in my world. â€Å"And by ‘we,' † added Jerome, â€Å"I mean you four.† He nodded toward Peter, Cody, Hugh, and me. â€Å"I'm sorry,† I said. â€Å"Let me make sure I'm following this. You've signed us up for some sort of bowling league. One that you aren't even going to participate in. And this is somehow going to prove your employees' ‘evilness' to the world.† â€Å"Don't be silly. I can't participate. Bowling teams only have four people.† He didn't comment on the proving evilness part. â€Å"Well, hey, I'll totally yield my spot to you,† I said. â€Å"I'm not that great a bowler.† â€Å"You'd better become one.† Jerome's voice grew cold. â€Å"All of you had, if you know what's good for you. Nanette will be impossible to live with at the next company meeting if you lot lose.† â€Å"Gee, Jerome. I love bowling,† said Carter. â€Å"How come you never mentioned this to me before?† Jerome and Carter held gazes for several heavy seconds. â€Å"Because, unless you're ready to take a fall for the team, you can't really compete with us.† A funny smile fell over Carter's face. His gray eyes glinted. â€Å"I see.† â€Å"I don't really like your use of ‘us,' seeing as you've already written off any participation on your part,† I pointed out to Jerome, imitating his earlier snide tone. Peter sighed, looking rather woebegone. â€Å"Where on earth am I going to find tasteful bowling shoes?† â€Å"What's our team name going to be?† asked Cody. That immediately degenerated into a conversation of truly terrible suggestions, such as Soulless in Seattle and Split Decision. After almost an hour, I couldn't handle any more. â€Å"I think I'm going to go home,† I said, standing up. I had kind of wanted dessert but was afraid I'd be drafted for beach volleyball and cricket if I stayed much longer. â€Å"I brought the wine. You guys don't really need me anymore.† â€Å"When you get home, tell my wayward offspring that I need him to coach you guys,† said Jerome. â€Å"By ‘home,' I actually meant Seth's,† I said. â€Å"But if I see Roman, I'll let him know you've found a good use for his formidable cosmic powers.† Roman – Jerome's half-human son and my roommate – actually was a pretty good bowler, but I didn't want to encourage Jerome. â€Å"Wait!† Peter sprang up after me. â€Å"You have to draw for Secret Santas first.† â€Å"Oh, come on – â€Å" â€Å"No complaining,† he argued. He hurried to the kitchen and returned with a ceramic cookie jar shaped like a snowman. He thrust it toward me. â€Å"Draw. Whatever name you get is who you're buying for, so don't try to get out of it.† I drew a piece of paper and opened it up. Georgina. â€Å"I can't – â€Å" Peter held up a hand to silence me. â€Å"You drew the name. That's who you've got. No arguments.† His stern look stopped me from any more protests. â€Å"Well,† I pointed out pragmatically, â€Å"at least I have a few ideas.† To his credit, Peter sent me home with some chocolate fondue sauce and a Tupperware bowl filled with fruit and marshmallows. Hugh and Cody were running forward with the bowling team plan, trying to come up with a practice schedule. Jerome and Carter said little and instead kept watching each other in a speculative, knowing way that was typical of them. It was hard to read much on their faces, but for once, Jerome gave off the vibe of having the upper hand. I left Capitol Hill for Seattle's University District and Seth's condo. All the windows were dark when I pulled up, and I couldn't help a smile. It was almost eleven. Seth must have called it an early night, something I'd been urging him to do for a while. Thinking of that, my smile faded as quickly as it had come. A few months ago, Seth's sister-in-law, Andrea, had been diagnosed with ovarian cancer. The disease had been pretty far advanced when caught, and although she'd almost immediately gone into treatment, the outcome still wasn't promising. Worse, the treatments had taken a huge physical toll on her, one that was testing the family's strength. Seth was frequently helping them out, especially when his brother Terry was working, since it was harder for Andrea to care for their five daughters now. Seth had been sacrificing both sleep and his writing career to look after them. I knew it was necessary. I loved Seth's family and had helped them out as well. But I still hated seeing Seth run himself down and knew that it hurt him to put his work on hold. He claimed his writing was the least of his problems right now and had time before deadlines were an issue, particularly since his next two books were queued for printing next year. I couldn't argue against that, but the sleep issue? Yeah, I was on him a lot about that and glad to see my words had gotten through tonight. I used my key to let myself in and slipped through the condo as silently as possible. I practically lived here lately and had no trouble finding my way around furniture in the darkness. When I reached his bedroom, I could just barely make out his form wrapped up in covers, softly outlined in the light of his alarm clock. I quietly took off my coat and then shape-shifted into a cotton babydoll nightgown. It was sexy but not blatantly so. I planned on sleeping with him tonight, for real. I slid into bed and pressed myself up against his back, lightly tossing an arm over him. He stirred slightly, and I couldn't resist pressing a kiss against his bare shoulder. The scent of cinnamon and musk washed over me as he snuggled closer. Despite sternly chastising myself that he needed to sleep, I lightly ran my fingers along his arm and sneaked in another kiss. â€Å"Mmm,† he murmured, rolling over toward me. â€Å"That feels nice.† A few things hit me at once. First, Seth didn't wear any sort of cologne or aftershave that smelled like cinnamon. Second, Seth's voice didn't sound like that. Third, and perhaps most important, Seth wasn't in bed with me. I didn't mean to scream as loudly as I did. It just kind of happened. I was out of the bed in a flash, groping for the light switch on the wall while the intruder attempted to get up. He ended up getting tangled in the covers and falling off the bed with a loud thump, just as I found the light. I promptly reached for a weapon, but seeing as this was Seth's bedroom, my options were limited. The heaviest, most dangerous object I could readily grab ahold of was Seth's dictionary, a leather-bound monstrosity that he kept on hand because he â€Å"didn't trust the Internet.† I stood poised and ready to literally throw the book at the intruder as he scrambled to his feet. As he did and I got a good look at him, I noticed something crazy. He looked . . . familiar. Not only that, but he kind of looked like Seth. â€Å"Who are you?† I demanded. â€Å"Who are you?† he exclaimed. He seemed more confused than anything else. I don't think he found the threat of a five foot four woman with a dictionary all that frightening. Before I could answer, a hand touched my arm. I yelped and threw the dictionary out of instinct. The guy dodged, letting the book crash harmlessly against the wall. I spun around to see who'd touched me and found myself looking into the eyes of a white-haired woman with gold cat-eye glasses. She was wearing flowered pajama bottoms and a pink sweatshirt with a crossword puzzle on it. She was also wielding a baseball bat, which was pretty astonishing – not just because it was more dangerous than a dictionary but also because I hadn't known Seth owned one. â€Å"What are you doing here?† she asked fiercely. She glanced over at the shirtless, dumbfounded guy. â€Å"Are you okay?† For half a second, I actually toyed with the idea that I had somehow let myself into someone else's condo. Like, maybe I was just one door over. This scene was so ridiculous that a mix-up seemed far more likely. It was only the obvious evidence – like my key and Seth's University of Chicago teddy bear watching this spectacle – that drove home the fact that I was indeed where I was supposed to be. Suddenly, the sound of the front door opening and closing rang through the condo. â€Å"Hello?† came a blessedly familiar voice. â€Å"Seth!† exclaimed all three of us in unison. Moments later, Seth appeared in the doorway. As usual, he looked adorable. His reddish brown hair was typically unkempt, and he was wearing a Dirty Dancing T-shirt that I'd never seen before. Despite my panic and confusion over this current situation, the concerned part of me still noted the little signs of fatigue on Seth's face, the dark circles and lines of weariness. He was thirty-six and usually looked younger than his age. Not today. â€Å"Seth,† said the bat-wielding woman. â€Å"This lady broke into your house.† He looked at each of us in turn before resting his gaze on her. â€Å"Mom,† he said quietly, â€Å"that's my girlfriend. Please don't bludgeon her.† â€Å"Since when do you have a girlfriend?† asked the guy. â€Å"Since when do you have a baseball bat?† I asked, recovering my composure. Seth cut me a wry look before gently trying to remove the bat from the woman's hands. She didn't let go. â€Å"Georgina, this is my mom, Margaret Mortensen. And that's my brother Ian. Guys, this is Georgina.† â€Å"Hi,† I said, feeling surprise of a different sort. I'd heard a lot about Seth's mother and younger brother but hadn't expected to meet them anytime soon. Seth's mother didn't like to fly, and Ian was . . . well, from the stories Seth and Terry told, Ian was just hard to track down in general. He was the wayward Mortensen brother. Margaret relinquished the bat and put on a polite but wary smile. â€Å"It's very nice to meet you.† â€Å"Ditto,† said Ian. I now understood why he looked familiar. Aside from the fact I'd probably seen a picture of him somewhere, he also shared some of Seth's and Terry's features. He was tall like Seth, but with Terry's thinner face. Ian's hair was all brown, with no coppery hint, but it had that same messy look that Seth's did. Except, on closer examination, I had the feeling Ian's had been purposely styled that way with the help of much time and product. Seth suddenly did a double take between Ian and me. He didn't even have to say anything for me to guess the question on his mind. Or questions, perhaps. My nightgown and Ian's shirtlessness undoubtedly raised a number of them. Ian's defense came swift and certain. â€Å"She got into bed with me.† â€Å"I thought he was you,† I said. Seth's mother made a strange noise in her throat. â€Å"You were supposed to be on the couch,† said Seth accusingly. Ian shrugged. â€Å"It's uncomfortable. And you weren't home yet, so I figured there was no harm done. How was I supposed to know some woman was going to come manhandle me in my sleep?† â€Å"I didn't manhandle you!† I cried. Seth rubbed his eyes, again reminding me how exhausted he was. â€Å"Look, what's done is done. Why don't we all just go to bed – where we're supposed to – and then get to know each other in the morning, okay?† Margaret eyed me. â€Å"She's going to sleep in here? With you?† â€Å"Yes, Mom,† he said patiently. â€Å"With me. Because I'm a grown man. And this is my home. And because in thirty-six years, this isn't the first woman to stay over with me.† His mother looked aghast, and I groped for a more comfortable topic. â€Å"Your shirt's great.† Now that she wasn't threatening to strike me, I could see that the crossword spelled out her five granddaughters' names. â€Å"I love the girls.† â€Å"Thank you,† she said. â€Å"Each one of them is a blessing, born within the holy confines of wedlock.† Before I could even fumble a response to that, Ian groaned. â€Å"Lord, Mom. Is that from that Web site I told you not to order from? You know their stuff's made in China. I know this woman who could have made you one out of sustainable organic fabric.† â€Å"Hemp is a drug, not a fabric,† she told him. â€Å"Good night, you guys,† said Seth, pointing his brother to the door. â€Å"We'll talk in the morning.† Margaret and Ian murmured their good nights, and she paused to kiss Seth on the cheek – which I actually thought was pretty cute. When they were gone and the door was closed, Seth sat on his bed and buried his face in his hands. â€Å"So,† I said, coming to sit beside him. â€Å"Exactly how many women have stayed over in thirty-six years?† He looked up. â€Å"None who were caught by my mother in so little clothing.† I plucked at the skirt of the nightgown. â€Å"This? This is tame.† â€Å"I'm sorry about that,† he added, waving vaguely toward the door. â€Å"I should've called and warned you. They just drove into town tonight – unannounced, of course. Ian can't be expected to do what people expect. It would ruin his reputation. They showed up at Terry's, but there's no room for them there, so I sent them on ahead since they were so tired. I had no idea it would result in you trying to sleep with my brother.† â€Å"Seth!† â€Å"Kidding, kidding.† He picked up my hand and kissed the top of it. â€Å"How are you? How was your day?† â€Å"Well, I tried my best to keep Santa from getting drunk and then found out Jerome signed us up for a Hellish bowling league.† â€Å"I see,† said Seth. â€Å"So. The usual.† â€Å"Pretty much. What about you?† The small smile that had been tugging at his lips fell. â€Å"Aside from unexpected family? The usual too. Terry was out late with work stuff, so I was there all night with the girls while Andrea rested. Kendall has to build a papier-mache solar system, so that was fun for everyone.† He held up his hands and wiggled fingers coated in white powder. â€Å"And let me guess. No writing?† He shrugged. â€Å"It's not important.† â€Å"You should've called me. I could've watched them while you wrote.† â€Å"You were working and then . . . what, it was fondue night, right?† He stood up and stripped off his shirt and jeans, getting down to green flannel boxers. â€Å"How did you know that?† I asked. â€Å"I barely knew that.† â€Å"I was on Peter's e-mail list.† â€Å"Well, regardless, it doesn't matter. And that mall job is nothing. I could have been over here in a flash.† He stepped into his bathroom and returned a few moments later with a toothbrush in his mouth. â€Å"That job is nuffing. Haf any of your interfeews panned out?† â€Å"No,† I said, not adding that I hadn't gone on any other interviews. Everything paled compared to Emerald City. The conversation was put on pause while he finished brushing his teeth. â€Å"You should be doing something better,† he said, once he was done. â€Å"I'm fine where I'm at. I don't mind it. But you . . . you can't keep going on like this. You're not getting enough sleep or working.† â€Å"Don't worry about it,† he said. He turned off the light and crawled into bed. In the dimness, I saw him pat the spot beside him. â€Å"Come over here. It's just me, I promise.† I smiled and curled up beside him. â€Å"Ian didn't smell right, you know. I mean, he smelled good, but not like you.† â€Å"I'm sure he spends gratuitous amounts of money to smell good,† muttered Seth through a yawn. â€Å"What's he do for a living?† â€Å"Hard to say. He's always got new jobs. Or no job. Whatever money he's got goes toward carefully maintaining his hard-fought, effortless lifestyle. Have you seen his coat?† â€Å"No. The only clothing of his I've seen is his boxers.† â€Å"Ah. Well, it must be in the living room. It looks like it came from a thrift store but probably cost four figures.† He sighed. â€Å"Although, I shouldn't be too hard on him. I mean, yeah, he'll probably hit me up for money while he's here, but I can't knock him and Mom coming out to help. At the very least, they can help watch the kids now.† I wrapped my arms around Seth and breathed in his scent. It was the right one, and it was intoxicating. â€Å"And you can catch up on some writing.† â€Å"Maybe,† he said. â€Å"We'll see how it goes. I just hope I'm not babysitting Mom and Ian more than the girls.† â€Å"How bad of an impression did I make on her?† I asked. â€Å"Not that bad. I mean, no worse than any woman – scantily clad or otherwise – would've made who was spending the night with me.† He kissed my forehead. â€Å"She's not so bad. Don't be fooled by her conservative Midwest grandma act. I think you guys will get along.† I wanted to ask if Maddie had met Margaret and, if so, how they'd gotten along. I bit my tongue on the question. It didn't matter. It was in the past, and Seth and I were the present. Sometimes, especially staying here as much as I did, I felt a little weird remembering that Maddie had lived with him too. There were still little touches here and there that bore the mark of her influence. For example, Margaret was most likely staying in Seth's office, which had a futon, courtesy of Maddie's ingenuity. She'd been the one to suggest he get it to help make the office double as a guestroom. Maddie had gone; the futon had stayed. I tried not to think about those things very often, though. In the big picture, they didn't matter. Seth and I had come through too much for me to get hung up on something like that. We'd overcome the problems in our relationship. I'd accepted his mortality and his decision to risk his life by being physical with me. True, I still rationed our sex life, but the fact that I allowed it at all was a big concession for me. Meanwhile, he accepted the terrible truth that I was often out sleeping with other men in order to sustain my existence. They were difficult things for us both, but they were worth it for us to be together. Everything we'd gone through was worth it. â€Å"I love you,† I told him. He placed a soft kiss on my lips and pulled me closer. â€Å"I love you too.† Then, in an echo of my thoughts, he added, â€Å"You make it all worthwhile. All this stuff I'm dealing with†¦. I can do it because you're in my life, Thetis.† Thetis. That was his longtime nickname for me, coming from the shape-shifting goddess in Greek mythology who'd been won by a steadfast mortal. He called me that all the time – and Letha, only once. I thought again about that night. The troubled feelings it stirred never seemed to go away, but I once again tried to force them aside. It was another of those little things that I was trying not to let bug me. It was nothing compared to the greatness of our love, and like my friends had said, Seth had probably overheard the name. I fell into a contented sleep, only to be awakened abruptly around dawn. My eyes flew open, and I sat upright. Seth shifted and rolled over but wasn't awakened by my sudden movement. I stared around the room, my heart racing. I'd been jolted out of sleep by an immortal presence, one I didn't know. It had felt demonic. There was nothing here now, visible or invisible, but I knew for a fact some servant of Hell had just been in the room. This wasn't the first time I'd had unwelcome visitors in my sleep, often ones with nefarious intentions. Of course, I'd felt this demon just now, and demons – being higher immortals, not a lesser human-turned-immortal like me – could mask their immortal signature. If he or she had wanted to sneak around or hurt me unannounced, it could have done so. Whoever this was hadn't cared about discovery. I slipped out of bed and continued studying the room, looking for some sign or reason for the demon's passage. I was certain there would be one. There. Out of the corner of my eye, I caught a flash of red – in my purse. There was a business envelope sitting on top of it. I hurried over and scooped up the envelope. It was warm to my touch, but as I quietly opened it, I began to feel cold. That feeling intensified as I pulled out a letter printed on official Hell stationery. No good could come of this. Sunset had filtered more than enough light into the room to read by. The letter was addressed to Letha (alias: Georgina Kincaid), from Hell's HR: This is the thirty-day notice for your trans fer. Your new assignment will begin on January 15. Please make travel arrangements to leave Seattle and report to your new location in a timely manner.

Saturday, January 11, 2020

Patterns and trends in health among society Essay

Gender Women’s life expectancy is higher than men; women typically live five years longer than men (Stretch and Whitehouse 2012. In 2002, life expectancy at birth for females born in UK was 81 years, compared with 76 years for males. This contrasts with 49 and 45 years respectively at the turn of the last century in 1901(Sikin, L undated). Another reason why women live longer could be because men tend to smoke and drink more alcohol than women in general. Men also take more risk than women; Women have less chance in getting cardiovascular disease, like heart attack and stroke. Women usually develop these problems usually in their 70s and 80s, about 10 years later than men, who develop them in their 50s and 60s (Blue, L 2008). Another reason why women live longer could be because men in their late teens and 20s go through something called ‘’testosterone’’ (Blue, L 2008). Testosterone is when the level of hormones is high and changeable, this can create dangerous behaviors. For e.g. they may not wear seatbelts; they drink alcohol and they can become aggressive. These kinds of behaviors can lead to higher death rates for males. Men also take risk more than women; expert claims that men take more risk, making them twice as adventurous and carefree than female. However in 2011 bps state that woman often takes more risk than men. Psychological Science – a journal of the Association for Psychological Science – has shown the reality of what type of person is prone to taking chances is more complicated than first thought. The study found that despite stereotypes, females sometimes take more risks than men and adolescents can be as  cool-headed as any other demographic. (3). they have found out that men are prone to financial gambles and women often take social risks. Another reason why women life expectancy is higher because men tend to do dangerous sports such as rugby, surfing, motorcycle racing and skiing. In 2002 statistic said that females born in the UK live up to 81 years, whereas males live up to 76 years. This contrast with 49 and 45 years respectively at the turn of the last century in 1901 (2). This is a table is from 2007-2009 about life expectancy in different parts of the UK. In the UK, males and females expect to spend more than 80 per cent of their lives in very good health or general health from birth. Falling to around 57 per cent at the age of 65 (1). In recent years males are taking care of their health more than females. However in today’s society it is believed that female’s health has improved more than males. Social class Statistic produced a biases picture. They believe that people in the lowest social class work in dangerous industries. This causes higher rates of illness. Therefore it is not the class but age and employment of people that causes high levels of illness and lower life expectancy. /http://www.statistics.gov.uk/cci/nugget.asp?id=1007 Ethnicity All ethnic minorities have higher rates of still births, perinatal moralities (death within 1 week), and neo-natal mortality (within 1 month). Ethnicity backgrounds tend to have shorter life expectancy. Children from Asian families have higher rates of getting rickets. Only Afro-Caribbean’s and Pakistanis continue to show ‘excess mortality throughout infancy’ (Whitehead 1992). Afro-carribeans more likely to be admitted to mental health units, men more so than women and more likely to be sectioned. Once there they are more likely to receive harsh treatment e.g.- electro-shock therapy, anti psychotics. Age Geographical location The black report Internet Blue, L (2008) Why Do Women Live Longer Than Men [online] Available at: http://www.time.com/time/health/article/0,8599,1827162,00.html http://www.ons.gov.uk/ons/rel/disability-and-health-measurement/health-expectancies-at-birth-and-age-65-in-the-united-kingdom/2008-10/index.html Sikin, L (undated) Life expectancy [online] Available at: http://www.agediscrimination.info/statistics/Pages/LifeExpectancy.aspx The telegraph (2012) Men twice as likely to take risks [online] Available at: http://www.telegraph.co.uk/science/evolution/9005552/Men-twice-as-likely-to-take-risks.html

Friday, January 3, 2020

Using Modified Dna Inserted From An Organism With A...

Gene therapy is a rapidly developing technology first used in 1990.1 It involves the use of modified DNA inserted into an organism with a missing or mutated sequence. There are two methods of delivering this correction into the patient’s cells. In the viral method, a virus containing the vector with the corrected form of the gene, infects the cell naturally. Adenoviruses, adeno-associated viruses, lentiviruses, and retroviruses can all be used. They each utilize a different method of delivery and form of DNA. Adeno-associated viruses and lentiviruses are the easiest forms to construct.2 The corrected DNA faces many obstacles to gene expression and ultimately protein production. The viruses must target and enter the correct cell, avoid†¦show more content†¦Until the understanding of nucleases such as zinc finger nucleases was improved, gene therapy mainly focused upon single gene disorders that required a protein to be produced. With the discovery of nucleases, researc hers were then able to first target genes in order to disrupt the mutations and then correct them. The more successful delivery method utilizes a double stranded break in order to get the corrected sequence to be incorporated. This is called homologous recombination. Non-homologous recombination is when the double stranded break is made and then allowed to crash back together. It can be used to knock-out unwanted genes or for disease models and HIV therapy.2 Although there is a lot of potential for the field of gene therapy, there are some disadvantages that can make its use dangerous or ineffective. The disruption of a gene can be induced in an undesired location within the DNA sequence. Without more targeted techniques such as zinc finger nucleases or emerging technologies such as TALENs or CRISPR, it is difficult to foresee where the breaks will occur. For example, lentiviruses can randomly integrate into TSS or transcription start sites that code for oncogenes that cause cancer. Disrupting or activating unknown genes is a dangerous game. TALENs and CRISPR are emerging methods that are helping to appease these problems. With the development and improvement of gene therapy, further applications have been discovered and attempted. In particular, gene